Interventions to Address Disparities in Liver Diseases and Liver Cancer (R01 - Clinical Trials Optional) | PAR 24 207

Opportunity Information: Apply for PAR 24 207

The National Institutes of Health (NIH) funding opportunity PAR-24-207, titled "Interventions to Address Disparities in Liver Diseases and Liver Cancer (R01 - Clinical Trials Optional)," supports research projects that test interventions aimed at reducing inequities in liver disease and liver cancer outcomes in the United States. The main focus is on designing and evaluating intervention strategies that meaningfully reduce disparities among groups that experience a disproportionate burden of liver-related illness and liver cancer, whether due to social, structural, economic, geographic, or health care access factors. The grant uses the NIH R01 mechanism, which typically supports well-developed, hypothesis-driven research projects, and it allows applicants to propose studies that may or may not include a clinical trial component.

A central feature of this opportunity is its emphasis on multi-level and/or multi-domain interventions. In practice, that means NIH is looking for approaches that go beyond a single, isolated change and instead address multiple influences on health and health care. Multi-level interventions may work at more than one layer at the same time, such as the patient or community level (education, navigation, adherence support), the clinical level (screening workflows, provider decision support), and the health system or policy level (referral pathways, coverage barriers, service integration). Multi-domain interventions similarly combine distinct strategy types, for example pairing behavioral support with care coordination, or combining community outreach with clinic-based quality improvement. The intent is to support interventions that are realistic in real-world settings and capable of narrowing outcome gaps in prevention, diagnosis, treatment, and survivorship related to liver diseases and liver cancer.

The opportunity falls under the NIH discretionary grant category and is aligned with the Education and Health funding activity category. It is associated with CFDA numbers 93.279, 93.307, and 93.393, which indicate the participating NIH program areas that may be involved in supporting liver disease, cancer, and related health disparity research. While the notice does not list a specific award ceiling or the expected number of awards in the provided summary fields, the R01 mechanism generally funds projects that have substantial scope, strong preliminary rationale, and a clearly articulated plan for implementation and evaluation. The "clinical trials optional" designation signals that NIH will consider both clinical trial applications and non-trial intervention studies, as long as the proposed work fits the intervention-and-disparities purpose of the announcement and adheres to NIH definitions and requirements if a trial is included.

Eligible applicants include a broad range of U.S.-based organizations, such as public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations with 501(c)(3) status, and nonprofit organizations without 501(c)(3) status (as long as they are not higher education institutions when listed in that category). The opportunity also explicitly highlights additional eligible applicant types that commonly serve populations experiencing health disparities, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs). This emphasis reflects the program's equity-driven purpose and encourages applications that are closely connected to affected communities and capable of conducting culturally responsive, community-engaged research.

Foreign (non-U.S.) organizations are not eligible to apply as applicant institutions, and non-U.S. components of U.S. organizations are also not eligible to apply. However, foreign components are allowed under NIH policy, meaning a U.S. applicant can include certain activities or collaborations conducted outside the U.S. if they meet the NIH definition of a foreign component and are appropriately justified. This structure maintains U.S.-based leadership and accountability for the project while allowing specific international elements when they are scientifically necessary and compliant with NIH Grants Policy Statement requirements.

Key administrative details include the opportunity's creation date of May 13, 2024, and an original closing date listed as January 7, 2028, indicating a multi-year window during which applications may be accepted under the announcement (subject to NIH submission cycles and any future updates). Overall, PAR-24-207 is designed to build a stronger evidence base for interventions that reduce liver disease and liver cancer disparities by funding rigorous, intervention-focused research that can be implemented in real health care and community settings and that targets the upstream and downstream factors driving unequal outcomes.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Interventions to Address Disparities in Liver Diseases and Liver Cancer (R01 - Clinical Trials Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279, 93.307, 93.393.
• This funding opportunity was created on 2024-05-13.
• Applicants must submit their applications by 2028-01-07.
• Eligible applicants include: Public and State controlled institutions of higher education, Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, Others.

Apply for PAR 24 207

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