Opportunity Information: Apply for PA 18 140
Applying Metabolomics to Drive Biomarker Discovery in Symptom Science (R01 Clinical Trial Optional) is a National Institutes of Health (NIH) grant opportunity that supports research aimed at discovering biomarkers related to symptoms by using metabolomics. The central idea is to use metabolomics, meaning the large-scale measurement and analysis of small molecules and metabolic products in biological systems, to deepen what is known about how symptoms arise, how they can be measured more objectively, and how symptom management can be improved. In practice, this kind of work can help move symptom science beyond self-report alone by identifying measurable biological signatures that correlate with symptom presence, severity, subtypes, trajectories over time, or response to interventions.
The opportunity uses the R01 mechanism, which is NIH's standard investigator-initiated research project grant intended for substantial, hypothesis-driven studies with clear aims, a rigorous design, and a strong analytic plan. The listing notes "Clinical Trial Optional," meaning applicants are allowed to propose studies that include clinical trials but are not required to do so. This flexibility makes it suitable both for observational biomarker discovery studies (for example, profiling metabolite patterns associated with fatigue, pain, sleep disturbance, nausea, anxiety, or cognitive symptoms) and for intervention studies where metabolomic biomarkers might be used to predict or track response, stratify participants, or illuminate mechanisms of symptom improvement or worsening.
The overall funding category is discretionary and is aligned with NIH health and education-related research priorities. The CFDA numbers associated with the announcement are 93.213 and 93.361, which correspond to NIH program areas that commonly include symptom science and related biomedical research. The funding opportunity number is PA 18 140, and the announcement was created on 2017-11-06. The original closing date listed in the source information is 2019-05-07, which signals that the opportunity was open during that period; anyone considering applying now would typically need to confirm whether the announcement has been reissued, extended, or replaced by a newer FOA.
A notable feature of this opportunity is its broad eligibility. In addition to the standard range of U.S. applicants often seen in NIH announcements, it explicitly includes a wide variety of institutional types and community-connected organizations. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofits with and without 501(c)(3) status (outside of higher education); for-profit organizations (other than small businesses); small businesses; and other unspecified eligible entities. It also calls out additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and even non-U.S. entities (foreign organizations). This breadth reflects NIH's interest in supporting diverse research settings, populations, and multidisciplinary teams, which can be especially important for symptom research where context, environment, and population heterogeneity strongly influence symptom experiences and outcomes.
While the source text does not provide an award ceiling or the number of expected awards, the intent is clear: to stimulate rigorous biomarker discovery efforts that use metabolomics as the primary technology or a key component of a broader biomarker strategy. Competitive projects under this announcement would generally be expected to show strong rationale for the symptom(s) being studied, clear definitions and measurement strategies for symptoms, appropriate biospecimen selection and handling procedures, robust metabolomics platforms and quality control, and thoughtful statistical and bioinformatics approaches to biomarker identification and validation. Because biomarker discovery is vulnerable to false positives and replication problems, strong applications typically emphasize careful cohort selection, control of confounding factors (such as medications, diet, comorbidities, and circadian effects), and plans for independent validation or replication when feasible.
In short, this NIH R01 opportunity was designed to accelerate symptom science by funding research that uses metabolomics to discover biomarkers that can improve understanding of symptom biology, enable more objective assessment, and ultimately support better symptom management and clinical decision-making across diverse populations and settings.Apply for PA 18 140
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Applying Metabolomics to Drive Biomarker Discovery in Symptom Science (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213, 93.361.
- This funding opportunity was created on 2017-11-06.
- Applicants must submit their applications by 2019-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 18 140) also looked into and applied for these:
| Funding Opportunity |
|---|
| Early Phase Clinical Trials in Imaging and Image-Guided Interventions (R01 Clinical Trial Required) Apply for PAR 18 011 Funding Number: PAR 18 011 Agency: National Institutes of Health Category: Education, Health Funding Amount: $250,000 |
| Research on Informal and Formal Caregiving for Alzheimer's Disease (R21 Clinical Trial Optional) Apply for PAR 18 179 Funding Number: PAR 18 179 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Applying Metabolomics to Drive Biomarker Discovery in Symptom Science (R21 Clinical Trial Optional) Apply for PA 18 158 Funding Number: PA 18 158 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Addressing Unmet Needs in Persons with Dementia to Decrease Behavioral Symptoms and Improve Quality of Life (R01 Clinical Trial Optional) Apply for PA 18 147 Funding Number: PA 18 147 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Improving Individual and Family Outcomes through Continuity and Coordination of Care in Hospice (R01 Clinical Trial Optional) Apply for PA 18 148 Funding Number: PA 18 148 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Personalized Strategies to Manage Symptoms of Chronic Illness (R21 Clinical Trial Optional) Apply for PA 18 156 Funding Number: PA 18 156 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Innovative Questions in Symptom Science and Genomics (R01 Clinical Trial Optional) Apply for PA 18 139 Funding Number: PA 18 139 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Use of Technology to Enhance Patient Outcomes and Prevent Illness (R21 Clinical Trial Optional) Apply for PA 18 163 Funding Number: PA 18 163 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Addressing Unmet Needs in Persons with Dementia to Decrease Behavioral Symptoms and Improve Quality of Life (R21 Clinical Trial Optional) Apply for PA 18 165 Funding Number: PA 18 165 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Personalized Strategies to Manage Symptoms of Chronic Illness (R01 Clinical Trial Optional) Apply for PA 18 138 Funding Number: PA 18 138 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Mechanisms, Models, Measurement, and Management in Pain Research (R21 Clinical Trial Optional) Apply for PA 18 159 Funding Number: PA 18 159 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Symptom Management in HIV-Infected Individuals with Comorbid Conditions (R21 Clinical Trial Optional) Apply for PA 18 161 Funding Number: PA 18 161 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Health Promotion Among Racial and Ethnic Minority Males (R21 Clinical Trial Optional) Apply for PA 18 162 Funding Number: PA 18 162 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Use of Technology to Enhance Patient Outcomes and Prevent Illness (R01 Clinical Trial Optional) Apply for PA 18 145 Funding Number: PA 18 145 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Self-Management Interventions and Technologies to Sustain Health and Optimize Functional Capabilities (R01 Clinical Trial Optional) Apply for PA 18 146 Funding Number: PA 18 146 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Symptom Management in HIV-Infected Individuals with Comorbid Conditions (R01 Clinical Trial Optional) Apply for PA 18 143 Funding Number: PA 18 143 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Altered neuronal circuits, receptors and networks in HIV-induced Central Nervous System (CNS) dysfunction (R21- Clinical Trial Not Allowed) Apply for RFA MH 18 611 Funding Number: RFA MH 18 611 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Palliative Care Needs of Individuals with Advanced Rare Diseases and Their Family Caregivers (R01 Clinical Trial Optional) Apply for PA 18 149 Funding Number: PA 18 149 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Innovative Questions in Symptom Science and Genomics (R21 Clinical Trial Optional) Apply for PA 18 157 Funding Number: PA 18 157 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Self-Management Interventions and Technologies to Sustain Health and Optimize Functional Capabilities (R21 Clinical Trial Optional) Apply for PA 18 164 Funding Number: PA 18 164 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
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