Population Genomic Screening in Primary Care Coordinating Center(U01 -Clinical Trials Optional) | RFA HG 24 022

Opportunity Information: Apply for RFA HG 24 022

The National Institutes of Health (NIH) is funding a Coordinating Center through a cooperative agreement (U01; clinical trials optional) under the opportunity titled "Population Genomic Screening in Primary Care Coordinating Center" (RFA-HG-24-022). The main purpose is to stand up and support a coordinated, multi-site network focused on population-level genomic screening in primary care settings. The larger goal is practical and implementation-focused: identify, test, and refine real-world approaches for bringing genomic screening into routine primary care in ways that are clinically workable, scalable, and likely to improve care delivery.

This NOFO is specifically for the Coordinating Center, which is meant to function as the hub of the overall network. In a typical NIH network structure, a coordinating center provides the operational backbone: aligning participating sites around shared goals, helping to standardize workflows and data elements, supporting communications and meetings, tracking milestones, and generally keeping multi-institution activities moving in the same direction. Here, that coordination role is especially important because the program is designed as a network with multiple moving parts that must stay integrated over time, including clinical implementation in primary care and the sequencing infrastructure that produces genomic results.

The opportunity runs in parallel with two companion funding announcements that cover the other core components of the network: one for the Clinical Groups (RFA-HG-24-021) and one for the Sequencing Center (RFA-HG-24-023). The intent is that these three funded components operate together as a single program. Applicants should read the NOFO as part of this larger ecosystem: the Coordinating Center is not being funded in isolation, but to work hand-in-hand with the clinical sites doing the on-the-ground screening and the sequencing center generating and returning genomic information used in care.

From an administrative standpoint, this is a discretionary federal funding opportunity using the cooperative agreement mechanism, which signals substantial NIH involvement during the life of the award compared to a standard research grant. The activity category is health, and the listed CFDA number is 93.172. The funding agency is NIH, and the original application due date is December 2, 2024. While the source text does not provide an award ceiling or expected number of awards, the structure implies NIH intends to select a single coordinating center or a small number of awards to fulfill the coordination function for the network.

Eligibility is broad across U.S.-based organizations and governmental entities. Eligible applicants include state, county, and city/township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations other than federally recognized governments; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other categories identified by NIH. The NOFO also highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions.

At the same time, the NOFO is explicit about foreign restrictions. Non-domestic (non-U.S.) entities are not eligible to apply. Non-domestic components of U.S. organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. In practical terms, the coordinating function, staffing, and program operations supported by this award must be fully U.S.-based under NIH policy.

In plain language, this grant is aimed at building the infrastructure and coordination capacity needed to make population genomic screening feasible inside primary care, not as a small pilot but as a networked effort intended to surface best practices for implementation. The Coordinating Center is the entity that makes the network function as a unified program by organizing collaboration across the funded clinical groups and the sequencing center, ensuring common approaches where needed, and helping generate the operational lessons that will inform broader adoption of genomic screening in everyday primary care.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Population Genomic Screening in Primary Care Coordinating Center(U01 -Clinical Trials Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172.
• This funding opportunity was created on 2024-08-14.
• Applicants must submit their applications by 2024-12-02. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA HG 24 022

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