Opportunity Information: Apply for RFA HG 24 022
The National Institutes of Health (NIH) is funding a Coordinating Center through a cooperative agreement (U01; clinical trials optional) under the opportunity titled "Population Genomic Screening in Primary Care Coordinating Center" (RFA-HG-24-022). The main purpose is to stand up and support a coordinated, multi-site network focused on population-level genomic screening in primary care settings. The larger goal is practical and implementation-focused: identify, test, and refine real-world approaches for bringing genomic screening into routine primary care in ways that are clinically workable, scalable, and likely to improve care delivery.
This NOFO is specifically for the Coordinating Center, which is meant to function as the hub of the overall network. In a typical NIH network structure, a coordinating center provides the operational backbone: aligning participating sites around shared goals, helping to standardize workflows and data elements, supporting communications and meetings, tracking milestones, and generally keeping multi-institution activities moving in the same direction. Here, that coordination role is especially important because the program is designed as a network with multiple moving parts that must stay integrated over time, including clinical implementation in primary care and the sequencing infrastructure that produces genomic results.
The opportunity runs in parallel with two companion funding announcements that cover the other core components of the network: one for the Clinical Groups (RFA-HG-24-021) and one for the Sequencing Center (RFA-HG-24-023). The intent is that these three funded components operate together as a single program. Applicants should read the NOFO as part of this larger ecosystem: the Coordinating Center is not being funded in isolation, but to work hand-in-hand with the clinical sites doing the on-the-ground screening and the sequencing center generating and returning genomic information used in care.
From an administrative standpoint, this is a discretionary federal funding opportunity using the cooperative agreement mechanism, which signals substantial NIH involvement during the life of the award compared to a standard research grant. The activity category is health, and the listed CFDA number is 93.172. The funding agency is NIH, and the original application due date is December 2, 2024. While the source text does not provide an award ceiling or expected number of awards, the structure implies NIH intends to select a single coordinating center or a small number of awards to fulfill the coordination function for the network.
Eligibility is broad across U.S.-based organizations and governmental entities. Eligible applicants include state, county, and city/township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations other than federally recognized governments; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other categories identified by NIH. The NOFO also highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions.
At the same time, the NOFO is explicit about foreign restrictions. Non-domestic (non-U.S.) entities are not eligible to apply. Non-domestic components of U.S. organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. In practical terms, the coordinating function, staffing, and program operations supported by this award must be fully U.S.-based under NIH policy.
In plain language, this grant is aimed at building the infrastructure and coordination capacity needed to make population genomic screening feasible inside primary care, not as a small pilot but as a networked effort intended to surface best practices for implementation. The Coordinating Center is the entity that makes the network function as a unified program by organizing collaboration across the funded clinical groups and the sequencing center, ensuring common approaches where needed, and helping generate the operational lessons that will inform broader adoption of genomic screening in everyday primary care.Apply for RFA HG 24 022
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Population Genomic Screening in Primary Care Coordinating Center(U01 -Clinical Trials Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172.
- This funding opportunity was created on 2024-08-14.
- Applicants must submit their applications by 2024-12-02. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is titled "Population Genomic Screening in Primary Care Coordinating Center" with the funding opportunity number RFA-HG-24-022.
Which federal agency is offering this opportunity?
The funding agency is the National Institutes of Health (NIH).
What type of award mechanism is being used?
This opportunity uses a cooperative agreement mechanism (U01). Clinical trials are optional under this mechanism, as stated in the opportunity description.
What does a cooperative agreement (U01) imply about NIH involvement?
A cooperative agreement indicates substantial NIH involvement during the life of the award compared to a standard research grant. In practice, that means NIH is expected to have an active role in the program as it progresses, consistent with how cooperative agreements typically operate.
What is being funded under this specific NOFO?
This NOFO is specifically for a Coordinating Center. The Coordinating Center is intended to serve as the operational hub of a coordinated, multi-site network focused on population-level genomic screening in primary care settings.
What is the main purpose of the Coordinating Center?
The Coordinating Center is meant to stand up and support a coordinated, multi-site network. Its role is to provide the operational backbone that helps participating sites stay aligned, integrated, and moving in the same direction over time.
What kinds of activities would a Coordinating Center typically support in an NIH network?
Based on the description provided, the Coordinating Center is expected to help align participating sites around shared goals, support standardization of workflows and data elements, support communications and meetings, track milestones, and generally coordinate multi-institution activities so the network functions as a unified program.
What is the overall program trying to accomplish?
The larger goal is practical and implementation-focused: to identify, test, and refine real-world approaches for integrating population genomic screening into routine primary care in ways that are clinically workable, scalable, and likely to improve care delivery.
Is the Coordinating Center funded as a standalone project?
No. The Coordinating Center is intended to operate as part of a larger ecosystem. It is not being funded in isolation; it is designed to work hand-in-hand with other funded components of the program.
What are the companion funding announcements, and what do they cover?
Two companion funding announcements run in parallel: one for the Clinical Groups (RFA-HG-24-021) and one for the Sequencing Center (RFA-HG-24-023). Together with this Coordinating Center award, these components are intended to operate as a single program.
How is the network structured across its funded components?
The program structure described includes (1) Clinical Groups conducting on-the-ground clinical implementation of population genomic screening in primary care settings, (2) a Sequencing Center generating and returning genomic information used in care, and (3) a Coordinating Center functioning as the hub that keeps the overall network aligned and operationally integrated.
Why is coordination especially important in this program?
The description emphasizes that the network has multiple moving parts that must remain integrated over time, including clinical implementation in primary care and sequencing infrastructure that produces genomic results. The Coordinating Center is positioned as the entity that helps keep these pieces connected and coordinated.
What is the CFDA number associated with this opportunity?
The listed CFDA number is 93.172.
What is the activity category for this opportunity?
The activity category is health.
What is the application due date?
The original application due date is December 2, 2024.
How many awards will NIH make, and what is the award ceiling?
The provided information does not include an award ceiling or an expected number of awards. However, the structure described suggests NIH intends to select a single coordinating center or a small number of awards to fulfill the coordination function for the network.
Who is eligible to apply (in general terms)?
Eligibility is broad across U.S.-based organizations and governmental entities. The opportunity lists many eligible applicant types across government, higher education, nonprofit, and for-profit sectors, as well as other categories identified by NIH.
Which government entities are listed as eligible applicants?
Eligible governmental applicants include state governments, county governments, city or township governments, special district governments, and independent school districts. Federally recognized Native American tribal governments are also listed as eligible.
Are institutions of higher education eligible to apply?
Yes. Public and state-controlled institutions of higher education and private institutions of higher education are listed as eligible applicants.
Are nonprofit organizations eligible to apply?
Yes. Nonprofits with 501(c)(3) status (other than institutions of higher education) and nonprofits without 501(c)(3) status (other than institutions of higher education) are listed as eligible.
Are for-profit organizations eligible to apply?
Yes. For-profit organizations other than small businesses are listed as eligible, and small businesses are also listed as eligible.
Are tribal organizations eligible if they are not federally recognized tribal governments?
Yes. The eligibility list includes tribal organizations other than federally recognized governments.
Are public housing authorities eligible?
Yes. Public housing authorities and Indian housing authorities are listed as eligible applicants.
Are faith-based or community-based organizations eligible?
Yes. The opportunity highlights faith-based or community-based organizations among additional eligible applicant types.
Are minority-serving institutions specifically mentioned as eligible?
Yes. The opportunity highlights Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are included among the highlighted eligible applicant types.
Are eligible federal agencies included as eligible applicants?
Yes. The opportunity highlights eligible federal agencies among eligible applicant types.
Are regional organizations eligible to apply?
Yes. Regional organizations are listed among the highlighted eligible applicant types.
Are non-U.S. (foreign) organizations eligible to apply?
No. Non-domestic (non-U.S.) entities are explicitly not eligible to apply.
Can a U.S. organization apply if part of the work will be performed by a non-U.S. component?
No. Non-domestic components of U.S. organizations are not eligible to apply, and foreign components (as defined in the NIH Grants Policy Statement) are not allowed.
Does the opportunity allow foreign components under NIH policy?
No. The NOFO states that foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
What does the foreign restriction mean in practical terms for this Coordinating Center?
In practical terms, the coordinating function, staffing, and program operations supported by this award must be fully U.S.-based under NIH policy, consistent with the stated restriction against non-domestic entities, non-domestic components, and foreign components.
What setting is this program focused on?
The program is focused on population-level genomic screening in primary care settings, with an emphasis on approaches that can fit into routine primary care.
Is the emphasis more on basic research or real-world implementation?
The description emphasizes practical, implementation-focused work: identifying, testing, and refining real-world approaches that are clinically workable and scalable for use in routine primary care.
How does the Sequencing Center fit into the overall program?
Based on the description, the Sequencing Center is the component responsible for generating and returning genomic information that is used in care, and it operates alongside the Clinical Groups and Coordinating Center as part of a single integrated network.
How do the Clinical Groups fit into the overall program?
The Clinical Groups are described as the on-the-ground sites implementing population genomic screening in primary care, operating as part of the network alongside the Sequencing Center and coordinated through the Coordinating Center.
What is the intended impact of funding a Coordinating Center for this network?
The intended impact is to provide the infrastructure and coordination capacity needed to make population genomic screening feasible within primary care at a network level, and to help generate operational lessons and best practices that can inform broader adoption of genomic screening in everyday care.
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