Opportunity Information: Apply for RFA NS 23 027
Collaborative Opportunities for Multidisciplinary, Bold, and Innovative Neuroscience (COMBINE) (RM1 Clinical Trial Optional) is an NIH/NINDS funding opportunity (RFA-NS-23-027; CFDA 93.853) that supports large, tightly coordinated team-science projects aimed at ambitious neuroscience questions within the mission of the National Institute of Neurological Disorders and Stroke. This announcement is a reissue of an earlier FOA (RFA-NS-22-011) that was updated to align with NIH Data Management and Sharing Policy (DMSP) requirements; the reissue does not change the application due dates or where the application is reviewed. The award mechanism is the RM1, and clinical trials may be proposed but are not required, meaning teams can submit either basic, translational, or clinically oriented projects as long as the work fits NINDS priorities.
A defining feature of COMBINE is that it is built for true integration across disciplines and investigators. Applications must be led by a multi-PI team of at least three and no more than six Program Directors/Principal Investigators, organized around a single, shared scientific goal that cannot be achieved by one lab working alone. The FOA emphasizes collaboration that creates synergy, with active coordination and managed team interactions, rather than a loose federation of labs. In practical terms, NINDS is looking for projects where each part of the science depends on and strengthens the others, with shared strategy, shared milestones, and a coherent narrative that demonstrates why the team structure is essential to success.
The program is also clearly positioned as different from the NINDS P01 model. Instead of multiple semi-independent subprojects bundled together, COMBINE expects one cohesive and well-integrated research plan with a singular focus, one unified set of specific aims, and a single consolidated budget (not a set of subproject budgets). The intent is to fund bold, challenging research that has a realistic path to major advances, and teams are encouraged to define transformative objectives that can produce concrete, compelling outcomes within a five-year project period. In other words, the application should read like one high-impact project executed by a coordinated leadership group, not several parallel projects sharing an umbrella topic.
Eligibility is broad and includes many common applicant types such as public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, and various levels of government (state, county, city/township, special districts), as well as independent school districts and public housing authorities/Indian housing authorities. Federally recognized Native American tribal governments are eligible, and the FOA also highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, HBCUs, Tribally Controlled Colleges and Universities, faith-based or community-based organizations, eligible federal agencies, regional organizations, tribal governments that are not federally recognized, and U.S. territories or possessions. At the same time, the FOA draws clear lines on foreign participation: non-domestic (non-U.S.) entities and non-domestic (non-U.S.) components of U.S. organizations are not eligible to apply, but foreign components are permitted when they meet the NIH definition in the NIH Grants Policy Statement.
Key administrative details provided include that the opportunity is categorized as a discretionary grant in the health area, with an original closing date of 2024-10-08 and a creation date of 2023-05-15. The award ceiling and expected number of awards are not specified in the supplied listing. Overall, COMBINE is best understood as NINDS support for high-risk/high-reward, interdisciplinary neuroscience led by a small leadership coalition, where the strongest applications will show genuine interdependence among the approaches, strong coordination plans, and a clear five-year arc toward outcomes that would be difficult to reach through conventional single-lab or loosely coordinated multi-project structures.Apply for RFA NS 23 027
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Collaborative Opportunities for Multidisciplinary, Bold, and Innovative Neuroscience (COMBINE) (RM1 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853.
- This funding opportunity was created on 2023-05-15.
- Applicants must submit their applications by 2024-10-08. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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