Opportunity Information: Apply for PA 18 823
The National Institute on Aging (NIA), part of the National Institutes of Health, issued this discretionary grant opportunity (Funding Opportunity Number PA-18-823) to support R01 research projects that use existing resources from the CALERIE trial (Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy). The central focus is on secondary analyses, meaning applicants are expected to work with previously collected CALERIE data and/or stored CALERIE biospecimens rather than launching new human intervention studies. Consistent with that purpose, the announcement is explicitly labeled "Clinical Trial Not Allowed," signaling that the proposed work should not involve initiating a new clinical trial or assigning participants to interventions; instead, it should leverage CALERIE materials to answer additional mechanistic and translational questions.
The scientific goal of the program is to deepen understanding of how sustained caloric restriction (CR) affects human health. In practical terms, the NIA is looking for analyses that clarify CR-related changes in risk factors for chronic diseases and, importantly, the cellular and molecular pathways that may mediate those effects in humans. Applications are therefore expected to move beyond high-level observations and aim for more detailed mechanistic insight, such as linking CR exposure to biological markers, pathways, or profiles that help explain why certain physiological changes occur and how those changes might translate into altered disease risk.
This opportunity sits within the NIH "Health" activity category (CFDA number 93.866) and uses the standard NIH research project grant mechanism (R01). Because it is an R01, projects are generally expected to be hypothesis-driven, analytically rigorous, and substantial in scope, with clear aims, appropriate statistical or bioinformatic methods, and a plan for making full use of the CALERIE dataset and/or biospecimen repository to generate publishable, field-advancing findings.
Eligibility is broad and includes many types of U.S. and non-U.S. organizations. Domestic eligible applicants listed include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); and small businesses. The FOA also explicitly highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and foreign (non-U.S.) entities.
Key administrative details in the posted record include the original creation date of June 8, 2018, with an original closing date listed as September 7, 2021. The award ceiling and expected number of awards are not specified in the provided source fields, which typically means applicants would need to consult the full FOA text and NIH funding guidance for budget expectations, paylines, and related administrative constraints. Overall, the opportunity is designed for investigators who can use CALERIE data and biospecimens to extract deeper, mechanistically informative insights about caloric restriction in humans and its potential relevance to aging and chronic disease risk.Apply for PA 18 823
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Analyses of CALERIE Data and Biospecimens to Elucidate Mechanisms of Caloric Restriction (CR)-Induced Effects in Humans (R01 - Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on 2018-06-08.
- Applicants must submit their applications by 2021-09-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
FAQs: NIA/NIH Grant Opportunity PA-18-823 (CALERIE Secondary Analyses, R01)
What is this funding opportunity?
This is a discretionary research grant opportunity from the National Institute on Aging (NIA), part of the National Institutes of Health (NIH), under Funding Opportunity Number (FON) PA-18-823. It supports R01 research projects that use existing resources from the CALERIE trial (Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy).
What is the main purpose of the program?
The program is intended to deepen understanding of how sustained caloric restriction (CR) affects human health by using previously collected CALERIE data and/or stored CALERIE biospecimens to answer additional research questions.
What type of research is being requested?
The focus is on secondary analyses using existing CALERIE resources. Applications are expected to be hypothesis-driven and analytically rigorous, consistent with the scope of an NIH R01 research project.
Does this opportunity allow new clinical trials?
No. The announcement is explicitly labeled "Clinical Trial Not Allowed." Proposed work should not initiate a new human intervention study or assign participants to interventions.
If clinical trials are not allowed, what kinds of activities are appropriate?
Appropriate activities include analyzing previously collected CALERIE datasets and/or conducting studies using stored CALERIE biospecimens to generate new insights, including mechanistic and translational findings, without starting a new intervention trial.
What is meant by "secondary analyses" in this context?
Secondary analyses means the research uses data and/or biospecimens that were already collected through the CALERIE trial, rather than collecting new intervention data from newly enrolled participants.
What is the scientific focus area?
The scientific goal is to clarify how sustained caloric restriction influences risk factors for chronic diseases and to identify cellular and molecular pathways that may mediate those effects in humans.
Is the program looking for mechanistic research or only descriptive findings?
The program is aimed at deeper mechanistic and translational insight, not only high-level observations. Applications are expected to link caloric restriction exposure to biological markers, pathways, or profiles that help explain observed physiological changes and their relevance to disease risk.
What grant mechanism is used?
The opportunity uses the standard NIH research project grant mechanism, R01.
What does using the R01 mechanism imply for the project scope?
Because it is an R01, projects are generally expected to be substantial in scope, hypothesis-driven, and methodologically strong, with clear aims and appropriate analytic approaches (including statistical and/or bioinformatic methods) that make full use of CALERIE data and/or biospecimens.
What existing resources must applicants use?
Applicants are expected to use existing CALERIE trial resources, specifically previously collected CALERIE data and/or stored CALERIE biospecimens.
Which NIH activity category and CFDA number are associated with this opportunity?
This opportunity is within the NIH "Health" activity category and is associated with CFDA number 93.866.
Who is eligible to apply?
Eligibility is broad and includes many U.S. and non-U.S. organization types listed in the opportunity information, spanning government entities, educational institutions, nonprofits, for-profits (other than small businesses), small businesses, and additional categories highlighted by the FOA.
Are U.S. government entities eligible?
Yes. Domestic eligible applicants listed include state, county, and city or township governments, as well as special district governments.
Are educational institutions eligible?
Yes. Eligible domestic applicants include independent school districts; public and state-controlled institutions of higher education; and private institutions of higher education.
Are tribal entities eligible?
Yes. Eligible applicants include federally recognized Native American tribal governments and tribal organizations that are not federally recognized.
Are housing authorities eligible?
Yes. Public housing authorities and Indian housing authorities are listed as eligible applicants.
Are nonprofits eligible?
Yes. Nonprofits with or without 501(c)(3) status (other than institutions of higher education) are included in the eligible applicant list.
Are for-profit organizations eligible?
Yes. For-profit organizations (other than small businesses) are eligible, and small businesses are also listed as eligible.
Are foreign (non-U.S.) applicants eligible?
Yes. The eligibility section explicitly includes foreign (non-U.S.) entities.
Are U.S. territories or possessions eligible?
Yes. The FOA highlights eligibility for U.S. territories or possessions.
Does the opportunity highlight specific institution types or community organizations?
Yes. The FOA explicitly highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, HBCUs, TCCUs, faith-based or community-based organizations, eligible federal agencies, and regional organizations.
When was this opportunity created and when did it close?
The posted record lists an original creation date of June 8, 2018, and an original closing date of September 7, 2021.
Is the award ceiling listed?
No. The award ceiling is not specified in the provided source fields.
Is the expected number of awards listed?
No. The expected number of awards is not specified in the provided source fields.
Where should applicants look for budget expectations or other NIH administrative constraints?
Based on the record provided, applicants would need to consult the full FOA text and NIH funding guidance for information such as budget expectations, paylines, and related administrative constraints.
What kinds of outcomes is NIA likely expecting from funded projects?
Projects are expected to produce analytically rigorous, publishable findings that advance the field by extracting deeper mechanistic insights from CALERIE data and/or biospecimens related to caloric restriction, aging, and chronic disease risk factors.
Browse more opportunities from the same category: Health
Next opportunity: Role of Gut Microbiome in Regulating Reproduction and Its Impact on Fertility Status in Women Living with and Without HIV (R01 - Clinical Trial Optional)
Previous opportunity: Collaborative Activities to Promote Cancer Cachexia Research (Admin Supp - Clinical Trial Not Allowed)
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PA 18 823
Applicants also applied for:
Applicants who have applied for this opportunity (PA 18 823) also looked into and applied for these:
| Funding Opportunity |
|---|
| Data Management and Coordinating Center (DMCC) for Rare Diseases Clinical Research Network (RDCRN) (U2C Clinical Trial Not Allowed) Apply for RFA TR 18 021 Funding Number: RFA TR 18 021 Agency: National Institutes of Health Category: Health Funding Amount: $3,500,000 |
| Sustained Release Innovation for HIV (SRI) (R61/R33 Clinical Trial Optional) Apply for RFA AI 18 006 Funding Number: RFA AI 18 006 Agency: National Institutes of Health Category: Health Funding Amount: $800,000 |
| NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required) Apply for PAR 18 828 Funding Number: PAR 18 828 Agency: National Institutes of Health Category: Health Funding Amount: $1,050,000 |
| NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33 Clinical Trial Required) Apply for PAR 18 829 Funding Number: PAR 18 829 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Orphans and Vulnerable Children II (OVC II) Activity Apply for 72052118R00016 Funding Number: 72052118R00016 Agency: Haiti USAID-Port Au Prince Category: Health Funding Amount: $19,950,000 |
| Developmental AIDS Research Center on Mental Health and HIV/AIDS (P30 Clinical Trial Optional) Apply for PAR 18 833 Funding Number: PAR 18 833 Agency: National Institutes of Health Category: Health Funding Amount: $750,000 |
| AIDS Research Center on Mental Health and HIV/AIDS (P30 Clinical Trial Optional) Apply for PAR 18 832 Funding Number: PAR 18 832 Agency: National Institutes of Health Category: Health Funding Amount: $1,500,000 |
| Modeling and Simulation to Optimize HIV Prevention Research (MS OPR) (R01 Clinical Trial not allowed) Apply for RFA AI 18 026 Funding Number: RFA AI 18 026 Agency: National Institutes of Health Category: Health Funding Amount: $400,000 |
| High-Priority Behavioral and Social Research Networks in Alzheimer's Disease and Alzheimer's Disease Related Dementias (R24 Clinical Trial Not Allowed) Apply for RFA AG 19 016 Funding Number: RFA AG 19 016 Agency: National Institutes of Health Category: Health Funding Amount: $250,000 |
| High-Priority Behavioral and Social Research Networks (R24 Clinical Trial Not Allowed) Apply for RFA AG 19 015 Funding Number: RFA AG 19 015 Agency: National Institutes of Health Category: Health Funding Amount: $250,000 |
| Global Infectious Disease Research Training Program (D43 Clinical Trial Optional) Apply for PAR 18 840 Funding Number: PAR 18 840 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Advancing mAbs to Achieve a Drug-free Sustained HIV Virologic Remission (U01 Clinical Trial Required) Apply for RFA AI 18 022 Funding Number: RFA AI 18 022 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Elucidating the Functional Roles of Non-Coding RNAs in Viral Infectious Diseases (R21 Clinical Trial Not Allowed) Apply for RFA AI 18 025 Funding Number: RFA AI 18 025 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Investigator Initiated Research in Computational Genomics and Data Science (R01 Clinical Trial Not Allowed) Apply for PAR 18 844 Funding Number: PAR 18 844 Agency: National Institutes of Health Category: Health Funding Amount: $500,000 |
| Investigator Initiated Research in Computational Genomics and Data Science (R21 Clinical Trial Not Allowed) Apply for PAR 18 843 Funding Number: PAR 18 843 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Halting TB Transmission in HIV-Endemic and Other High-Transmission Settings (R01 Clinical Trial Not Allowed) Apply for RFA AI 18 037 Funding Number: RFA AI 18 037 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIDCD Hearing Healthcare for Adults: Improving Access and Affordability (R21/R33 Clinical Trials Optional) Apply for RFA DC 19 001 Funding Number: RFA DC 19 001 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIMH Career Enhancement Award to Advance Autism Services for Adults and Transition-Age Youth (K18 Clinical Trials Required) Apply for RFA MH 19 101 Funding Number: RFA MH 19 101 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIMH Career Enhancement Award to Advance Autism Services for Adults and Transition-Age Youth (K18 Clinical Trials Not Allowed) Apply for RFA MH 19 100 Funding Number: RFA MH 19 100 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| The National Health and Aging Trends Study (U01 Clinical Trial Not Allowed) Apply for RFA AG 19 019 Funding Number: RFA AG 19 019 Agency: National Institutes of Health Category: Health Funding Amount: $550,000 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PA 18 823", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.